It is important to understand the hypothalamic-pituitary system and the intimate relation between nervous system and endocrine system. Better understanding of the interaction between the endocrine system and the nervous system, combined with the knowledge about the pathophysiology of the neurologic manifestations presented in the endocrine disorders might allow earlier diagnosis and better treatment of the endocrine disorders. Early diagnosis and treatment of hormonal imbalance can rapidly relieve the neurologic symptoms. It is valuable to think about 'endocrine disorder' as a cause of the neurologic manifestations. This article provides an overview of the neurologic manifestations found in various endocrine disorders that affect pediatric patients. It is important to recognize the neurologic signs and symptoms caused by the endocrine disorders while managing endocrine disorders. Endocrine dysfunctions may lead to various neurologic manifestations such as headache, myopathy, and acute encephalopathy including coma. The nervous system and the endocrine system are closely interrelated and both involved intimately in maintaining homeostasis.
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